1. Five invisible killers of liver damage
Toxin accumulation
1.Mycotoxin: Aflatoxin B1 (AFB1) inhibits RNA synthesis in hepatocytes, and a concentration of ≥0.1ppm will induce fatty degeneration
2.Endotoxin: Gram-negative bacteria die and release LPS, inducing Kupffer cell overactivation (damage rate ↑40%)
Nutritional imbalance
1.Choline deficiency leads to impaired apolipoprotein synthesis and a 3-fold increase in the rate of triglyceride deposition in the liver
2.When vitamin E is <50 IU/kg of diet, the liver's antioxidant capacity decreases by 67%
Drug damage
1.Excessive use of tetracycline antibiotics (＞20mg/kg·day) inhibits mitochondrial β-oxidation
2.Anthelmintic benzimidazoles induce cholestasis (alkaline phosphatase ALP increases to 300U/L↑)
Metabolic stress
1.In high-yielding laying hens/late fattening period, the liver lipid synthesis load is overloaded by 150%
2.Under heat stress, liver blood flow is reduced by 35%, and detoxification efficiency drops sharply
Pathogen invasion
1.Duck viral hepatitis (DHV) has a 72-hour mortality rate of >90%
2.Avian hepatitis E (HEV) causes subcapsular hematoma of the liver
2. Triple three-dimensional protection system
1.Nutritional fortification program
Phosphatidylcholine：Promote the output of very low density lipoprotein (VLDL) 500mg/kg for broilers and 800mg/kg for laying hens
Silybin Increases glutathione synthetase activity 15-20mg/kg body weight/day
Selenium yeast enhances glutathione peroxidase activity 0.3-0.5ppm
2. Precision medical intervention
Early warning :
Serological test: AST＞250U/L + GGT＞50U/L (indicating liver cell damage)
Imaging examination: Ultrasound shows enhanced echogenicity of liver parenchyma (Gold standard for fatty liver)
Emergency plan :
Detoxification injection: Reduced glutathione injection 15mg/kg intravenous injection
Bile clearance: Ursodeoxycholic acid 10mg/kg oral
3.Medical intervention system
First aid treatment
Detoxification injection: Reduced glutathione 15mg/kg intravenous injection (neutralizes toxins)
Bile clearance: Ursodeoxycholic acid 10mg/kg oral administration (improve congestion)
Chinese medicine assistance
Acute phase: Radix Isatidis + Folium Isatidis decoction (anti-inflammatory and jaundice)
Convalescent phase: Astragalus polysaccharide 0.1% mixed with feed (promote liver cell regeneration
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